Pernicious anemia or Macrocytic anemia is a deficiency symptoms of vit. B12. This is associated with lesions of the CNS described as subacute combined degeneration, due to the interference with the normal synthesis of nucleic acids, particularly DNA.
Chemistry- The structure of vitamin B12 consists of
1) Tetrapyrrole ring system-corrin
2) Cobalt occupying central place in the rig
3) Cynide is attached to cobalt
4) A nucleotide and
5) 6- methy benzinamidazole riboside which is attached at the one end to cobalt and at the other end to a side chain in ring IV through phosphate.
Cooling curves-
15 years ago
No comments:
Post a Comment